I reckon that as I've improved in ability, it's become easier to swap between mouthpieces.
Today I got a Brilhart Level Air for my alto (screeching, baffled duckbill metal thing) which I took to within seconds. I have a very specific idea of what I'm after, and this Brilhart lets me get it very easily.
Its predecessor was a Phil Barone custom, which he tells me is more or less an old Meyer. Lovely round, fat sounding mouthpiece, but lacking in the psychotic projection that I'm after. He designed it specifically for me as a tenor player doubling on alto; whereas now I'm playing alto in its own right. I orginally took to the Barone in seconds, perhaps because it was so much better than the dog rough Yani that came with the sax.
On the tenor I had more trouble getting to grips with mouthpieces, but I reckon that's cos it was a while ago, didn't know what I was after, and wasn't capable of getting the best from the mpcs.
My first decent one was an Otto Link ebonite 10* (yes 10*!!!!). It was beautiful, but took some real getting to grips with. Its only flaw was that, link the Barone, I couldn't get the projection I needed, though its deep, rumbling subtone was majestic.
I then got my hands on an Otto Link Metal NY 6*, which gave me the projection, but which didn't instantly give me the full dynamic range. It was almost the complete opposite to the 10*, and it took me months of persistence to get fully to grips with the quieter and deeper end of things.