There are so few people in that situation that any feedback will be questionable - others without teeth may have different sensitivity. You just need to try it to see whether you are comfortable.
The good news is that there should be very little biting when using a proper saxophone embouchure (in contrast to a clarinet embouchure).
Your oral cavity will be different due to the change in gap at the front of the mouth, so I suggest you compensate with a tall beak on the mouthpiece. You can certainly apply soft cushions to the top of the beak as well.