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Sorry if it wasn't clear - the first was absolutely considering modal improv on a single chord type tune.IMO the second is way better unless we are considering modal impro, e.g. jazz or funk wehere there is just one chord G7 and G is the tonal center.
If you have a IIm7 V7 I in C then any scale you may think of for the Dm7 and G7 (if you want to think scales) should be a C scale as above. C major or C harmonic minor are both good. Harmonic minor even if its a G9 or G13 as the Ab and Eb are bluesy sounding. And in this case mixolydian can be thrown out of the window.
With regards to your second part, I was hoping that was covered by my final point that mostly they're interchangeable.
