What do you use and how experienced are you? Maybe you need a slightly harder reed. I find the softer reeds go off very quickly and I now use 3s.
About four months ago I bought a box of 25 Rico orange tenor reeds. I assume that they are from the same production batch, but I found that they seem to show some variation. So far all of them have played, but some seem to require much more effort than others. Among the solutions I use are filing the tip down ever so slightly with an emery board or soaking them longer.